Synthesis, spectroscopic and cytotoxic studies of biologically active new Co (II), Ni (II), Cu (II) and Mn (II) complexes of Schiff base hydrazones

The synthesis, structure, spectral and biological studies of Cu (II), Ni (II), Co (II) and Mn (II) complexes of unsymmetrical Schiff base hydrazones ligand are described. Ligands are synthesized starting from cinnamaldehyde hydrazone with substituted salicylaldehyde. It is evident from the IR data that in all the complexes, only one part of the ligands is coordinated to the metal ion resulting mononuclear complexes. The ligand coordinates through the nitrogen atoms (N-N) of the hydrazone moiety and oxygen atom after deprotonation of the substituted salicylaldehyde fragment. The formulations,- [Cu(L)2], [Ni(L)2], [Co(L)2] and [Mn(L)2] are in accordance with elemental analyses, physical and spectroscopic measurements. The complexes are soluble in organic solvents. Molar conductance values in DMF indicate the nonelectrolytic nature of the complexes. For the observed magnetic moment and electronic spectral data possible has been discussed. All the complexes show a single line EPR signals. From all the available data, the probable structures for the complexes have been proposed. The compounds synthesized in present study have shown promising cytotoxic activity when screened using the in vitro method and at the same time were shown to have good activity when tested using the Ehrlich Ascites carcinoma (EAC) model. The antimicrobial screening showed that the Manganese complexes possess enhanced antimicrobial activity towards fungi

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