Synthesis, reactions and antimicrobial activity on some novel phthalazinones derivatives

A simple and efficient synthesis of [4-(3, 4-dimethylphenyl)-5, 6, 7, 8-tetrabromo-1-oxo-1Hphthalazin- 2-yl]-acetic acid hydrazide IV has been carried out. The obtained hydrazide IV has been used in synthesis of some interesting heterocycles such as pyrazolone, thiazolidinone,pyrimidine,benzoxazine lactam, rhodanine, quinazoline, benzoxazinoneVIIIXVII. The structures of these compounds were confirmed by IR,1HNMR,mass spectrum and elemental analysis. Some of the prepared compounds evaluated for their antibacterial activities against gram positive and gram-negative strain of bacteria for in vitro antibacterial activities

Author(s): Fatehia. K. Mohamed

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