Synthesis, physico-chemical and spectral studies of Hg(II) and Cu(II) complexes with sulfamethoxazole schiff base

Schiff bases derived from sulfa drugs act as good ligand to transition metal ions and they exhibit several coordination modes. The metal complexes of Cu(II) and Hg(II) have been synthesized with Schiff base of sulfamethoxazole [4-amino-N-(5-methyl-3-isoxazolyl) benzenesulfonamide] and salicylaldehyde. Sulfa drugs concentrate in the urine before being excreted and treat urinary tract infections. Conductometric titrations have suggested metal-ligand ratio of 1:2 for both Cu(II) and Hg(II) complexes. The ligand behaves as a bidentate with N, O donor atoms. Complexes have been synthesized and characterized by elemental analysis, IR and NMR spectral studies.

Author(s): Bharti Jaina, Suman Malikb, Neha Sharmaa and Shrikant Sharmac

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