Synthesis of thiazolidinone compounds: Part-II§. Synthesis of thiazolidin-4- one from schiff bases derived from 5-chloro-2-hydroxy-4-methylacetophenone

A series of new 2-(5-Chloro-2-hydroxy-4-methyl-phenyl)-2-methyl-3-phenyl-thiazolidin-4-one derivatives (MT-I to MT-VII) were synthesized from novel schiff base of 4-Chloro-5-methyl-2-(1-phenylimino-ethyl)-phenol (M-I to MVII) with thioglycolic acid in presence of anhydrous zinc chloride. The chemical structures of these compounds were confirmed by colour, physical constant and various spectral techniques viz, UV-Vis, FTIR spectral data and elemental analysis. These newly synthesized compounds were screened in vitro for their antimicrobial activity against varieties of fungal strain Saccharomyce cerevisiae, Candida albicans, Penicillum notatum, Alternaria alternate, Aspergillus niger at 500 and 1000 μg/mL. The 2-(5-Chloro-2-hydroxy-4-methyl-phenyl)-2-methyl-3-(4- methyl-2-nitro-phenyl)-thiazolidin-4-one, MT-IV and 2-(5-Chloro-2-hydroxy-4-methyl-phenyl)-3-(4-hydroxy-2- nitro-phenyl)-2-methyl-thiazolidin-4-one, MT-V, derivatives are showing marked activity against Saccharomyce cerevisiae, Candida albicans, as compare to the other derivatives.

Author(s): C. A. Nehete and C. J. Patil

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