Synthesis of spirochromanone derivatives as antimicrobial agents

A series of new methyl 3-[4-(4-oxo-6-phenyl-spiro [chromane-2,4'-piperidine]-1'-yl)sulfonyl phenyl]propanoate 5aj and N-[5-(1'-acetyl-4-oxo-spiro[chromane-2,4'-piperidine]-6-yl)-2-methyl-phenyl]-3-alkylamide or alkyl sulfonamide 9a-i has been synthesized and cheracterized via IR, 1H NMR, 13C NMR, MS elemental analysis. All the newly synthesized compounds were screened for their antibacterial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis and antifungal activity against Candida albicans. Some of the compounds exhibited moderate inhibition on bacterial and fungal growth as compared to standard drugs

Author(s): Nilesh N Gajera and Mukesh C Patel

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