Synthesis of some 2,3-disubstituted quinazolinone derivatives as antitubercular and antibacterial activity agents

Currently, one third of the world’s population is infected with Mycobacterium tuberculosis and 8.9 to 9.9 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased incidence of multi-drug resistant strains of M. tuberculosis, and the adverse effects of first and second-line antituberculosis drugs have led to renewed research interest in synthetic products in the hope of discovering new antitubercular leads. The reaction of 3-amino-2-(substituted phenyl quinazolin-4-one with 2-acetyl pyridine, 3-acetyl pyridine, 4- acetyl pyridine provided 2-substituted phenyl-(pyridine-4-yl-ethylideneamino) quinazolin-4-(3H)- one. The structure of the compounds has been confirmed by IR, 1HNMR, Mass spectral data and Elemental analysis. Antitubercular and antibacterial activities were performed by microbroth dilution and cup-plate method respectively. Few compounds have shown good antitubercular activity and better antibacterial activity compared to the standard drug.

Author(s): Rajasekaran Subramaniam

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