Synthesis of novel thiazolidin-4-one derivatives their antimicrobial and molecular docking studies

S. Shahavar Sulthana; S. Arul Antony; S. Syed Shafi

Abstract

Synthesis of novel thiazolidin-4-one derivatives their antimicrobial and molecular docking studies

Novel thiazolidin-4-one derivatives have been synthesized via Ullmann reaction followed by condensation of 1- nitrophenyl-4-piperidones with thiosemicarbazides and then cyclisation with ethylchloroacetate. Chemical structureof the synthesised compounds was elucidated by FT-IR, 1H NMR, 13C NMR, Mass and elemental analysis. The title compounds were tested for their antimicrobial activity and found to exhibit a variable degree of activity. Molecular docking studies done to investigate plausible mechanism of action towards the DNA topoisomerase IV receptor.

Author(s): S. Shahavar Sulthana, S. Arul Antony and S. Syed Shafi

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