Synthesis of novel click coumarins and biological evaluation

Rajesh Babu K.; V. Madhavarao

Abstract

Synthesis of novel click coumarins and biological evaluation

Owing to great importance of coumarins in their versatile biological behaviour, novel series of coumarinswere synthesized and cytotoxic study was conducted. Comparative antibacterial screening was performed with the existing series of coumarins which were synthesised from traditional method. Propargyloxy coumarins reacted with different azide derivatives in acid catalysis to yield triazolated coumarins. Reaction progress was monitored by TLC. The synthesised compounds were characterized by IR, H1 NMR, C13 NMR, ESIMS and Elemental analytical data

Author(s): Rajesh Babu K. and V. Madhavarao

Abstract | PDF