Synthesis of Mn(II), Co(II), Cu(II) and Zn(II) complexes with (E)- N'-(pyridine-2-ylmethylene)nicotinohydrazide and their evaluation of antimicrobial activities

Metal Complexes of (E)-N'-(pyridine-2-ylmethylene)nicotinohydrazide (PCNH) were prepared by treating it with various transition metal salts. The structure of the ligand was characterized by elemental, IR, 1H NMR, 13C NMR and Mass spectral studies and the metal complexes were characterized by elemental, molar conductance, IR, UV, 1H NMR and ESR studies. Magnetic studies and conductance measurements were also been carried out to establish the structure of the complexes. All the complexes have mononuclear structure and possess octahedral geometry. Redox behavior of the complexes has been investigated by Cyclic Voltametry at the glass carbon electrode in 0.1 M DMSO. Further, ligand and its metal complexes have been screened for in vitro to evaluate their activity against certain micro organisms.

Author(s): T. Chandrasekaran and M. Syed Ali Padusha

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