ISSN : 0976 - 8688
Der Pharmacia Sinica
Abstract
Synthesis of 4-(5ÃÆâÃâââ¬Ãâââ¢,6ÃÆâÃâââ¬Ãâââ¢,7ÃÆâÃâââ¬Ãâââ¢, 8ÃÆâÃâââ¬Ãâââ¢-tetrahydro-naphthalene)-1-tetralone
A new one-pot synthesis of 4-aryltetralone was discovered. This tandem process includes condensation of alphanaphthol with tetralin in presence of Lewis acids, most preferably by aluminium chloride followed by its hydrolysis yields 4-aryltetralone in fairy good yield under Friedel-Crafts conditions. The primarily advantage of present protocol is use of tetralin as a solvent as well as reactant. The structure of newly synthesized compounds were characterized by advanced spectral (IR, 1H-NMR, 13C-NMR and LC/MS) and analytical (elemental analysis and melting point) techniques. The synthesized compound was subjected to powder X-ray diffraction shows its crystalline nature. The operational simplicity and easily scalable process are major benefits.
Author(s): Kundan Singh Shekhawat, K. K. Jhankal, Ramswaroop and D. K. Sharma
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