Synthesis of 2-substituted 3-cyano-8-ethyl carboxylate-2-methylthio-4-oxo-4Hpyrimido[ 2,1-b] benzothiazole

Novel series of 3-cyano-8-ethyl carboxylate-2-methylthio-4H-pyrimido[2,1-b]benzothiazole (III) & its 2-substituted derivatives [IV(a-d),V(a-c),VI(a-c),VII(a-d)] synthesized by the reactions of 2-amino benzothiazole (I) and ethyl-2- cyano-3, 3-bismethyl thioacrylate (II). 3-cyano-8-ethyl carboxylate-2-methylthio-4H-pyrimido[2,1-b]benzothiazole (III) possesses replaceable active methylthio group at 2-position, the susceptibility of it towards condensation with different reagents like aryl amines, heteryl amines, phenols and compounds containing active methylene group has been investigated. These reactions resulted in the formation of 2-substituted derivatives of 3-cyano-8- ethylcarboxylate-2-methylthio-4H-pyrimido[2,1-b]benzothiazole (III) in DMF and catalytic amount of potassium carbonate. All the synthesized compounds are confirmed by their spectral data and elemental analysis.

Author(s): Santosh G. Badne

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