Synthesis, characterization and In-Vitro cytotoxic study of novel ligands and their metal complexes

A series of Cu(II) and Zn(II) complexes of Mannich bases L1 , L2 , L3 and L4 have been synthesized and characterized by spectroscopic methods such as UV, IR, 1H NMR, 13C NMR , Mass spectra, ESR spectra and physiochemical methods. The ligands act as a bidentate, coordinating through the oxygen/sulphur atom of urea/thiourea moiety and nitrogen atom of N-methyl piperazine/piperazine. The spectral studies confirm a six coordinate environment around the metal ion. The low molar conductance value in DMF indicates that the metal complexes are non-electrolytic nature. The magnetic moments and electronic spectral data suggest octahedral geometry for the Cu(II) and Zn(II) complexes. All the complexes have the general composition of [M(L)2(X)2] (M = Cu(II) and Zn(II); L = Mannich base and X = Cl ). All the Cu(II) complexes are paramagnetic and Zn(II) complexes are diamagnetic in nature. These compounds were also tested for in-vitro cytotoxic effect against human lung cancer cell (A549), colon cancer cell (HCT15) and normal cell lines (VERO).

Author(s): T.H. Mohamed Ahadu Shareef , M. Syed Ali Padusha and A. Kalilur Rahiman

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