Synthesis, characterization and chelating properties of benzofuran-1,3,4-oxadiazole combined molecules having p-amino salicylic acid ligand

The Mannich reaction between 5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazole-2(3H)-thione (NFOD) and p-amino salicylic acid (SA) was give 2-hydroxy-4-((5-(naphtho[2,1-b]furan-2-yl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)methyl amino) benzoic acid(NFODMSA). The novel ligand was characterized by elemental analysis and spectral studies. The transition metal chelates viz. Cu2+, Ni2+ , Co2+ , Mn2+ and Zn2+ of NFODMSA were prepared and characterized by metal-ligand (M:L) ratio, IR and reflectance spectroscopies and magnetic properties. The antifungal activity of NFODMSA and its metal chelates was examined against various fungi

Author(s): Dr.G.D.Acharya, Govindkumar Ravindrakumar Varde

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