ISSN : 0976 - 8688
Synthesis of novel N-[2-chloro-4-(trifluoromethyl) phenyl]-4-(substituted phenyl)-6-methyl-2-thioxo-1,2,3,4- tetrahydropyrimidine-5-carboxamide (4a-o) was achieved by acid catalysed cyclocondensation of N-(2-chloro-4- (trifluoromethyl)phenyl)-3-oxobutanamide(1), thiourea(2) and Substituted Benzaldehydes(3). The structures of the synthesized compounds were confirmed on the basis of spectral and elemental analysis. The synthesized compounds were screened for antimicrobial activity.
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