Synthesis, characterization, and biological activity of new mannich base N-((2-hydroxyphenyl)(o-tolylamino)methyl)acrylamide

In the present study of a new Mannich base play a major role in biological process in view of this otoluidine Mannich base was synthesized by using o-toluidine, salicylaldehyde and acrylamide. The newly synthesized compound (TOSA) was characterized by elemental analysis, UV-Vis, FT-IR, FT-RAMAN, 1H NMR, 13C NMR, 2D homo cosy NMR and Mass spectral techniques. In addition to antibacterial and antifungal properties were tested against a panel of five pathogenic bacterial strains namely, (Staphylococcus aureus, Klebsielloa Pneumonia, Bacillus anthracis, Escherichia coli, and, Bacillus cereus) and antifungal activity against a panel of five pathogenic fungal strains namely Aspergillus fumigates, Aspergillus nidulans, Aspergillus terreus, Aspergillus flavus, Aspergillus niger. The Parallel experiments were also carried out with standard drugs (Norfloxacin for bacteria and Fluconazole for fungi).

Author(s): T. Thirugnanam, D. Tamilvendan and M. Amaladasan

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