Synthesis, characterization and biological activity of 4-thiazolidinone derivatives containing 1H-pyrazolo[3,4-b]pyridine nucleus

The thiazolidinone derivatives substituted at 2- and 3-position are associated with diverse biological activities. Considerable evidence has been accumulated to demonstrate the wide applications of thiazolidinone derivatives and also Pyrazolo[3,4-b]pyridine nucleus have drawn the attention of chemists due to diversified biological activities associated with it. In view of these findings, it appeared of interest to synthesize, newer thiazolidinone derivatives with better potency. The constitution of the synthesized products have been characterized by using elemental analysis (N), infrared and 1H-nuclear magnetic resonance spectroscopy and further supported by mass spectroscopy. All the compounds have been evaluated for their in vitro biological assay like antibacterial activity towards Gram positive and Gram negative bacterial strains and antifungal activity.

Author(s): D. S. Kundariya, P. K. Patel and B. M. Bheshdadia

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