Synthesis, characterization and antimicrobial study of N-Mannich base and its complex

In this study, we have synthesized Mannich base of N-[(2-hydroxyphenyl)(pyridine-2-yl)methyl]acetamide from acetamide solution with phenol and pyridine caboxaldehyde. A complex of the above compound also prepared with Nickel(II) chloride in methanol. Structures of the newly synthesized compounds were confirmed by elemental analyses, IR, UV-VIS & NMR. These compounds are characterized by physical and chemical methods. All the newly synthesized compounds were screened for their antimicrobial activity against gram positive Staphylococcus aureus, Bacillus subtilis, gram negative Escherichia coli, Pseudomonas aeruginosa, and Fungi Candida albicans. Both of the compounds showed a marked activity against the selected microorganisms. Metal complex has been found to possess more activity than the free ligand

Author(s): Meera Moydeen A.a, Syed Ali Padusha M.b, Hany El-Hamsharya, Mohamed H. El-Newehya and Salem S. Al-deyaba

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