Synthesis, characterization and antimicrobial evaluation of novel compounds containing 2- phenoxy-1, 3, 2-benzodioxa phosphole-2-oxide and 1, 3, 4 - oxadiazole system

New novel derivatives of 2-(4-substituted phenoxy)-1, 3, 2-benzodioxa phosphole-2-oxide with 1, 3, 4 -oxadiazole System were prepared by the reaction between 2-(4-substituted phenoxy)-1,3,2-benzodioxaphosphole-4- carbohydrazide-2-oxides 3(a-e) with p-substituted acetophenone (4) yielded the corresponding 2-(4-substituted phenoxy)-N’-(1-(4-substituted phenyl) ethylidene)-1,3,2-benzodioxaphosphole-4-carbohydrazide-2-oxide 5(a-t). These were allowed to undergo cyclization to develop 2-aryl-3-acetyl-1,3,4-oxadiazole system in the presence of aceticanhydride to give corresponding final products 1-(2-(4-substituted phenyl)-5-(2-(4-substituted phenoxy)-1,3,2- benzodioxa phosphole-4-yl-2-oxide)-2-methyl-1,3,4-oxadiazole-3(2H)-yl) ethanone 6(a-t). The chemical structures of these newly synthesized compounds were characterized by 1H-NMR, Mass, IR, C¹³-NMR and P³¹-NMR Spectral data. These newly synthesized compounds 6(a-t) were screened for their antibacterial and antifungal activity

Author(s): P. Jagadeeswara Rao, K. S. Bhavani Aishwarya, Y. N. Spoorthy, D. Ishrath Begum and L. K. Ravindranath

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