Synthesis and structural determination of novel heterocyclic derivatives of coumarin isothiocyanates

The aim of present work is to synthesize new coumarin heterocycles and elucidates their biological activity. For the synthesis, methyl substituted 1,2,4-triazole coumarin molecule was treated with CS2gives coumarin isothiocyanate, which is used as precursor molecule. This resultant coumarin isothiocyanates further condensed with thioglycolic acid, glycine, anthranilic acid, o-amino thiophenol and o-aminophenol which forms various heterocyclic derivatives like 1,3-thiazolidin, 2-thioxoimidazolidin, quinazolin, benzothiazol and benzoxazol. The synthesized compounds were confirmed by the spectral techniques. All the compounds were screened for their antimicrobial activities and have been found to exhibited significant activities.

Author(s): Sanjay K. Patil and Hrushikesh P. Deokar

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