Synthesis and Spectral Studies of 2-mercapto-5-methoxy-1H-benzimidazole:
An Imperative Medicinal Intermediate

Jabali J. Vora; Keyur P. Trivedi; Rahul S. Kshatriya

Abstract

Synthesis and Spectral Studies of 2-mercapto-5-methoxy-1H-benzimidazole: An Imperative Medicinal Intermediate

An improved, convergent and industrially useful process suitable for large-scale production of 2-mercapto-5- methoxy-1H-benzimidazole, required for synthesis of omeprazole, has been described. It is a proton pump inhibitor. In present work, reaction of 4-methoxy aniline with acetic anhydride gave N-(4-methoxyphenyl)acetamide(2), which on further processes like nitration followed by hydrolysis, reduction and cyclization gave title compound (6). Structure of the synthesized compound was established on the basis of spectral analyses like IR, NMR and MASS.

Author(s): Jabali J. Vora, Keyur P. Trivedi and Rahul S. Kshatriya

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