ISSN : 0976-8505

Der Chemica Sinica

Abstract

Synthesis and pharmacological evaluation of new benzimidazole derivatives

Benzimidazole, a physiologically active nucleus, has attracted the attention of many researchers from the point of its chemistry and biological activity. A good number of them have been also marked as drugs, albendazole (antihelmintic), carbenadazim (fungicide), emedastine (antihistamine), omeprazole (proton pump inhibitor), Droperidol and pimozide ( psychopharmacological agent), etc. The schematic protocol is fusing the moieties of benzimidazole and thiazolidinones and synthesizing novel 3-[1H-benzimidazole-2-yl-amino]-2- phenyl-1,3-thiazolidin-4-one, such five compounds are synthesized and characterized by its physical data like Molecular formula, Melting point (°C), Molecular weight & Yield %. The spectral analysis is carried for the synthesized compounds by IR and Mass spectrum. These structures with screening them for possible CNS activity like gross behavioral studies and locomotion activity


Author(s): Srinivas Bethi, Matta Vidyasagar, Rajamanohar.K, Venkateshwar Rao J and Sandeep Gummudavelly

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