Synthesis and in vivo anti-inflammatory activity of
a novel series of benzoxazole derivatives

Srinivas Ampati; Raju Jukanti; Vidya Sagar; Rama Ganta; Sarangapani M; a

Abstract

Synthesis and in vivo anti-inflammatory activity of a novel series of benzoxazole derivatives

Novel series of benzoxazole derivatives were prepared by the condensation of methyl-2-(2- aminothiazol-5-ylamino) benzo[d]oxazole-5-carboxylate with various aromatic aldehydes. The structures of the synthesized compounds were VI1-VI15 assigned on the basis of elemental analysis, IR, 1H NMR and mass spectroscopy. These compounds were also screened for antiinflammatory activity. The recorded percentage of inhibition showed a significant antiinflammatory activity when compared to the reference anti-inflammatory drug diclofenac sodium

Author(s): Srinivas Ampati , Raju Jukanti, Vidya Sagar, Rama Ganta, Sarangapani Manda

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