Synthesis and characterization of heterocyclic cyanine dyes

Cyanine dyes employed as fluorescence labels and sensors in vivo have attracted immense interest because their spectra reach the NIR region where biological matrix exhibits the lease absorption and auto-fluorescence background. The rationale for the present research work described in this paper pertains to the synthesis and characterization of novel, stable cyanine chromophores that heterocyclic triazole as an integral part. The starting material azidobenzene (I) was prepared from diazotization of aniline and followed by nucleophilic substitution using sodium azide. It was further reacted with propargyl alcohol under click reaction condition to get the alcohol (II). Compound (II) was oxidized using silica supported Jones reagent to get the triazole containing aldehyde (III). It was further condensed under knoevanogel conditions with two different heterocycle with active methylene groups to get the target compounds IV and V.

Author(s): S. Parvathy, P. T. Liji, A. Kalaiyarasi and B. R. Venkatraman

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