Synthesis and biological studies of triazole-thiazolidinone containing compounds

3-(4H-1, 2, 4-triazol-3-ylthio)propane hydrazide(1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 3-(4H-1,2,4-triazol-3-ylthio)-N’-arylidene propane hydrazide(2a-f) in good yields. Cyclo condensation of compounds (4a-f) with thioglycolic acid yields 3-(4H-1, 2, 4-triazol-3-ylthio)-N-(4-oxo-2- arylthiazolidin-3-yl) propanamide (3a-f). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

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