Synthesis and bioelectrochemical screening of modified Tolbutamide molecule

Tolbutamide is an antidiabetic drug. Its potency may be increased by modifying the drug by way of molecular modification. In the present study the drug has been modified by its complex formation with potassium bicarbonate and other organic compounds. The drug organic compound interaction has been studied using differential pulse polarography and direct current polarography. In KCl as supporting electrolyte of pH 3.4±0.1, tolbutamide produced a well defined peak at -1.02v and it’s modified forms at relatively higher negative. The change in peak potential and lowering in peak hight. Drug organic compound complaxation has completed

Author(s): Rakesh Choure , Neelam Vaidya and K.S. Pitre

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