Synthesis and antimycobacterial activity of Cu (II) complexes containing thiosemicarbazones ligand

Copper (II) thiosemicarbazone complexes derived from simple thiosemicarbazone. The compounds were characterised using various spectroscopic and analytical techniques, including NMR spectroscopy, mass spectrometry, infrared spectroscopy and elemental analysis. The copper (II) complexes were screened for in vitro antitubercular activity. Incorporation of the copper (II) centre into thiosemicarbazone scaffolds enhanced their efficacy against the Mycobacterium tuberculosis while this trend was not observed for the selected simple thiosemicarbazones against the Mycobacterium tuberculosis virulent strain NCSMTB
Author(s): Snehalkumar D. Patila, Rahul D. Kamblea, Shrikant V. Hesea, Ashok P. Achayaa, Bhaskar S. Dawanea, Jivan R. Koteb and Rajesh N. Gachhe

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