Synthesis and antimicrobial evaluation of some novel thiazole derivatives

Thiazole nucleus has been established as the potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics. A series of pyrazoline thiazole derivatives were synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material 2-amino-4-aryl thiazole (1) was synthesized via a multicomponent condensation between thiourea, acetophenone and bromine. The Compound 1 was reacted with p-chloroacetophenone and various substituted aldehydes to synthesize the intermediates (3a- 3d) which on cyclization with hydrazine hydrate yielded final products i.e. pyrazoline thiazole derivatives (4a- 4d). Synthesized compounds were purified, characterized and evaluated for their antimicrobial activity. Most of the compounds exhibited moderate to significant activities.

Author(s): Raghav Mishra, Isha Tomer, Priyanka, N. K. Sharma, K. K. Jha

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