Synthesis and antimicrobial activity of Cobalt (II), Nickel (II), and Copper(II) complexes of some 2'- hydroxychalcones

The complexes of the type ML2 [ where M=Cu (II), Ni (II) and Co (II)] L= 1-(2'-Hydroxy phenyl)-3-(1- Hydroxy, 2, 4- Dibromo phenyl)-2- propen-1-one and 1-(2'-Hydroxy-3'-Iodo-5'- methyl phenyl)-3-(1- Hydroxy 2, 4-dibromo phenyl)-2-propen-1-one. These ligands were prepared by the condensation of substituted 2'- Hydroxyacetophenones and 3, 5 dibromosalicylaldehyde. The structures of the complexes have been proposed by the analytical data, conductivity measurement, magnetic moment, IR, electronic spectral data and thermal studies. Analytical data confirmed 1:2 stoichiometry and the electronic spectral data suggest that all Co (II), Ni (II) complexes have octahedral geometry whereas Cu (II) complexes have square planar geometry. Presence of coordinated water molecules in Co (II) and Ni (II) complexes is confirmed by TGA studies. The conductivity data show that all these complexes are non electrolytes. The ligands and their metal complexes were screened for antibacterial activity against various bacteria like E.coli, S. typhi, S. aureus, B. subtilis and fungicidal activity against various fungi like P.chrysogenum, A. niger, F. moniliformae, and C.albicans

Author(s): Seema I Habib, Mohammed A Baseer and Praffullkumar A Kulkarni

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