Synthesis and antihypertensive activity of 4'-{2-[4-[2-(Substitutedphenyl)- 4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-yl-methyl}- biphenyl-2-carboxylic acids

Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, 1H NMR, 13C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of compounds containing biphenyl carboxylic acid with aromatic aryl aldehydes derivatives with Thiazoldine-4-one. The synthesized compounds 4'-{2-[4-[2- (Substituted-phenyl)-4-oxo-thiazolidin-3-yl]-phenyl} benzoimidazol-1-ylmethyl}-biphenyl-2- carboxylic acid react with mercaptoacetic acid and 4'-bromomethylbiphenyl-2-carboxylic acid and all synthesis compounds screened for Angiotension (A II) Receptor Antagonist antihypertensive activity with biphenyl carboxylic acid Schiff bases Thiazoldine-4-one shows good activity compared with losartan and Telmisartan.

Author(s): M. C. Sharma, D. V. Kohli , Smita Sharmab and A. D. Sharma

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