Syntheses, characterization and evaluation of some 1,3,4-tri substituted-5-pyrazolone derivatives as dual anti-inflammatory and antimicrobial agents

A series of 4-arylidene-3-methyl-1-phenyl-5-pyrazolone derivatives (2a–j) were synthesized by reacting various substituted aromatic aldehydes with 3-methyl-1-phenyl-5-pyrazolone through Knoevenagel condensation by conventional as well as by exposure to microwave irradiations. Structures of all new synthesized compounds were characterized on the basis of spectral data. The title compounds were screened for in vivo anti-inflammatory activity and in vitro antimicrobial activity. Among the synthesized derivatives, compounds 2b, 2f and 2h exhibited significant anti-inflammatory activity whereas compounds 2b, 2c, 2h and 2j emerged as the most active antibacterial agents. Compound 2b was identified as the most active member of the series with an interesting dual anti-inflammatory and antibacterial profile.

Author(s): Rajeev Verma, Pooja Chawla and Shailendra K. Saraf

Abstract | PDF

Share This Article