Surface Features of Interfacial Layers of Solid-Phase Gramicidin Antibiotic an AFMInvestigations

Objective: The present 3D-AFM- investigations introduce important conclusive remarks enhance scientific community to understand why gramicidin family as antibiotic cream or ointment are structurally suitable with special surface topography enhance it to be applied as ointment.
Methods: Scanning electron microscopy (SEM) accompanied with atomic force microscopy (AFM) High-resolution Atomic Force microscopy (AFM) are used for testing morphological features and topological map of the investigated drug.
Results: Gramicidin has huge surface area due to poly-peptide chain configuration. Conclusion: AFM-investigation proved that gramicidin internal microstructure has poly-peptide chain fitted and suitable to be applied as interfacial cream/ointment antibiotic.

Author(s): Khaled M. Elsabawy

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