Structural and conformational studies of 1,3,3-trimethyl-2,6-diphenylpiperidin-4-one

In this title compound C20H23NO, the piperidine ring adopts chair conformation. The asymmetric unit consists of two molecules. The phenyl rings and the methyl group are substituted in the equatorial orientations of the heterocyclic ring. The dihedral angle between the two phenyl rings of both the molecules are 57.10(17) ° and 56.88(17)°respectively. Further the chain reaction which propagates along b axis with C-H...pi interactions stabilizes the structure . Heterocycles form a core of drug molecules with specific biological activities. QSAR studies are done continuously to improve the desired properties because stereo chemical orientations of groups present in organic molecules make the molecule active or inactive towards microbes, cell lines etc. So structural elucidation of organic molecules becomes an important area in organic synthesis. In this context we report the structure of the title compound.

Author(s): T. Mohandas, M. Velayutham Pillai, A. Ragu, T. Vidhyasagar and P. Sakthivel

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