Status of Certain Oxidative Stress Markers in Ischemic Heart Disease Patients with and Without Smoking in North Indian Punjabi Population

Background: Oxidative stress alters normal endothelial function, supporting proinflammatory, prothrombic, proliferative and vasoconstrictor mechanism that favor the development of atherosclerosis and vascular tissue injury. Aim: The aim of the present study was to investigate the status of oxidative stress in ischemic heart disease patients with smoking and without smoking by measuring malondialdehyde, superoxide dismutase, reduced glutathione and total antioxidant activity in North Indian Punjabi Population. Material and Methods: A well known 50 ischemic heart disease patients with smoking (n=25) and without smoking (n=25) admitted in the hospital and 50 normal healthy adult subjects who have no previous history of smoking as a control were recruited in the study for the evaluation of oxidative stress markers like malondialdehyde, superoxide dismutase, reduced glutathione and total antioxidant activity. Results: A highly significant (p<0.001) increase was found in malondialdehyde levels in ischemic heart disease patients with and without smoking in comparison to normal healthy control subjects while a significant reduction in the levels was observed in superoxide dismutase, reduced glutathione and total antioxidant activity in ischemic heart disease patients with and without smoking with respect to control subjects. Further we also observed in the present study that smoking significantly promoting the malondialdehyde levels upon significantly decrease the levels superoxide dismutase, reduced glutathione and total antioxidant activity in ischemic heart disease patients. Conclusion: All the above observations suggested that oxidative stress was induced in IHD patients and this study also pointed out that smoking accelerate the oxidative stress by promoting malondialdehyde levels while reducing superoxide dismutase, reduced glutathione and total antioxidant activity in circulation of IHD patients in the early age. Further studies with more sample size are needed to correlate these associations and accordingly future antioxidative therapy for beneficial of IHD patients.

Author(s): Kuldip Singh, Sukhjit Kaur and Rajiv Arora

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