Square wave voltammetry for electro catalytic detection of the antibacterialamoxicillin by a carbon paste electrode modified with zinc oxide nanoparticlesZnO@CPE. Analytical application: Milk, Human urine and Tap water

Amoxicillin is an antimicrobial of the penicillin class discovered in 1928, and is among the most widely used antibiotics to treat bacterial related infectious diseases, the purpose of this paper is to construct a simple platform for electrocatalytic detection of amoxicillin using a carbon paste electrode modified with zinc oxide nanoparticles. The ZnO@CPE modified electrode is constructed by simple and inexpensive processes using hydrothermal methods. Our results have shown that the ZnO/CPE modified electrode has excellent electrocatalytic activity compared to the unmodified CPE electrode with consistent, reproducible, stable behavior. The electrochemical behavior of the amoxicillin oxidation reaction is diffusion controlled and fully reversible. The effect of PBS pH on the antibacterial amoxicillin behavior shows that the number of protons and electrons was equal, The electrochemical parameters diffusion coefficient (D) and catalytic rate constant (k) were 1.135 10-4 cm2/s and 8.314 103 mol.l-1.s-1 respectively. The ZnO@CPE sensor was demonstrated a wide range of concentration linearity from 10-4 mol/l to 10-6mol/l with electrocatalytic current, the detection limit was estimated 2.91 10-7 mol/l according to Square-wave voltammetry (SWV) method.

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