Spectral and diuretic study of Cu(II) complex of Sulfonamides

The synthesis and characterization of Cu (II) complexes of three diuretic drugs acetazolamide, furosemide and hydrochlorothiazide are reported here. On the basis of elemental analyses, electrical conductivity and molecular weight data the adducts are assigned to the general composition [M(L)2]. All the adducts are paramagnetic in nature. The IR studies indicate that ligand is coordinated to metal through azomethine nitrogen atom. The electronic spectral data and magnetic moment values suggest square planar geometry and coordination number 4 for these complexes. We assessed diuretic activity of the ligand FSM-SA and complex FSM-SA-Cu in vivo following the protocol of Institutional Animal Ethical Committee norms. While studying the results of the experiment it was concluded the diuretic activity of the FSM-SA and FSM-SA-Cu was found to be more than the parent drug.

Author(s): Mamta Bhattacharya, S. A. Iqbal and Suman Malik

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