Serum Levels of L-amino Acid Oxidase in Ovarian Cancer Patients

Objective: The objective of this study was to determine the activity of L-amino acid oxidase in ovarian cancer patients. Material and Methods: In total, 50 women with ovarian cancer enrolled in this study. Serum samples were collected from ovarian cancer patients (n=50) before and after treatment and 50 healthy women were included in this study. In total 150 samples were analysed for the serum levels of Carbohydrate antigen 125 (CA-125) and L-amino acid oxidase (LAAO) activity. Results: In controls (n=50) the activity of L-amino acid oxidase were found to be 27.56±7.61 U/ml and the levels of CA-125 were found to be 14.62±10.11 U/L. In ovarian cancer patients, the pre treatment serum mean activity of LAAO was found to be increased significantly in serous (p<0.001), endometrioid (p<0.001), transitional (p<0.05), primary peritoneal (p<0.05), and in recurrent carcinoma patients (p<0.001). Post treatment activity of LAAO was found to be decreased compared to pre treatment levels in all histopathologic types of ovarian cancer patients except in those patients that cancer recurred. The pre treatment serum LAAO activity were found to be significantly increased (p<0.001) in patients with stage I & II disease and as well with stage III & IV disease. Conclusion: Taking potentiality of serum biomarkers into consideration, serum level of LAAO along with CA 125 could be a potential biomarkers in future predictor of cancer recurrence.

Author(s): Mangala Hegde, Yousef Rezaei Chianeh, Donald J. Fernandes, Jeevan Shetty and Pragna Rao

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