Selective properties of the anticancer proton preparation on basis of Greater Celandine Alkaloids NSC 631570 (Ukrain)

It is well known that all cells possess the negative charge and cancer cells have a much more nega-tive charge than normal cells. This property has been used for the creation of the anticancer prepara-tion on basis of greater celandine alkaloids with the positive charge NSC 631570 (Ukrain). The ex-periment has been carried out on basis of the sum of greater celandine alkaloids as well as on basis of the pure chelidonine with the aim to understand the mechanism of action of the preparation NSC 631570. Chelidonine is the tertiary alkaloid and due to it doesn’t have the property to fluoresce. Af-ter its transformation into the quartet alkaloid it becomes a proton, accumulate in cancer tumors very fast what is visible thanks to its autofleuorescence. The drug is strongly positively charged. Due to this it has an ability to be selectively accumulated in tumor tissue and to induce tumor cell apoptosis only in tumor cells without harmful effect on normal cells. Potent selective antitumor effect of NSC 631570 repeatedly proven by the results of clinical trials. Until now this preparation has been tested on over 100 cancer cell lines and on 12 normal cell lines and the results of the studies carried out in more than 120 universities and research centers (in particular at the National Cancer Institute (the USA)) have shown that the NSC 631570 killed only cancer cells without having damaged the normal cells what confirmed its selective effect.

Author(s): Wassil Nowicky

Abstract | Full-Text | PDF

Share This Article