Screening the Anti-ulcer Activity of Polyherbal Extract of Selected Medicinal Herbs Against Albino Wistar Rats

The main objective of this research was to elevate the better combination of known herbal drugs (Curcuma longa, Coriander sativum and Occimum sativum) for better anti-ulcer activity. Herbal extracts prepared from shade dried rhizomes, leaves using alcohol and water as solvents by soxhlet extraction, further all the extracts were subjected to preliminary phytochemical analysis. It was found out that, the extracts consists of alkaloids, glycosides, carbohydrates, steroids, proteins, amino acids, tannins, fixed oils and volatile oils. The anti-ulcer activity of polyherbral extracts was estimated in Albino rats weighing 150-200gms using pylorus ligation method. Biochemical parameters like ulcer index, total and free acidity, acid volume and pH were estimated in alcoholic and aqueous extracts. The alcoholic extract at a concentration of 400mg/kg produced more effect on ulcer induced models when compared with standard drug cimetidine (10mg/kg) with respect to other concentrations alcoholic extract significantly raised pH of gastric content, lowered the free and total acidity and ulcer index compared with control group. The results our conclusion was, the alcoholic extract exhibited more significant activity than aqueous activity.

Author(s): V. Swathi, Pusapati Madan Ranjit, M.Ramesh1 and Y.A. Chowdary

Abstract | PDF

Share This Article