Screening of antibacterial activity of some newly synthesised N-(4’oxo-2’-(aryl/ alkyl substituted) thiazolidin-2-one) -3-carboxamido-2H-chromen-2-ones

The synthesis of a range of N-[4’-oxo-2’-(substituted phenyl)-thiazolidin-3’-yl]-3-carboxamido- 2H-chromen-2-one (IV a-b, d, f, h-m) by condensation of N-(substituted benzylidene)-3- carbohydrazide-2H-chromen-2-one (III a-c, d, f, h-m) with thioglycolic acid in dimethyl formamide and Aluminium trichloride (0.05gms) and their evaluation of antibacterial activity by agar disc diffusion method. All the newly synthesized compounds tested for their Minimum Inhibitory Concentration (MIC) against all tested Gram positive and Gram-negative bacteria by micro dilution Broth method. Parent compound showed good activity. All compounds revealed better results against Gram positive as compared to Gram-negative bacteria. IV-b and IV-d were exhibited higher antibacterial activity when compared with all the synthesized analogues against all the tested micro organisms. Some of the coumarin derivatives showed more or less same activity indicating that number and position of substituted groups are not important regarding antibacterial activity. In addition IV-j was found most potent compound showing broad spectrum of antibacterial activity

Author(s): Indulatha V.N ., Gopal N1., Jayakar B2

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