Review on Hazardous Corticosteroids: Focus on Adverse Effects

During 1950's potential for corticosteroids therapy expanded in the management of chronic conditions. After this initial success in treating Rheumatoid arthritis, cortisone was used successfully to treat a range of other diseases as well. Various adverse effects are known to occur with their use. This review aimed to identify the most common and serious adverse effects. A search of review and research articles on the adverse effects of the corticosteroids class of steroid, as well as individual drugs from various publications made to study and analysis of various corticosteroid and their adverse effects. Data findings from the various research and review articles helped to understand the severity of the corticosteroid such as cortisone, prednisone, prednisolone, dexamethasone, methylprednisolone, fludrocortisone etc. The analysis of the more than 10 research articles and various online research publication website resulted adverse effects of the prednisone, prednisolone and dexamethasone which were responsible for the HPA axis suppression, hyperthyroidism and infection in which they produce susceptibility to the infections like varicella zoaster, aspergillus etc. There are many common adverse effects of the corticosteroid such as nausea, heartburn, headache, dizziness, fluid retention, irritability etc. Children weight gain, growth retardation and cushingoid features were most observed adverse effects due to the treatment of the prednisolone and budesonide.

Author(s): Datta Ughade*

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