Resveratrol suppresses prostate cancer progression in transgenic mice

Resveratrol (trans-3,4’,5-trihydroxystilbene) is a naturally occurring antifungal found in a variety of foods including the skin of red grapes and peanuts. Since the seminal report that resveratrol could inhibit multiple stages of carcinogenesis, it has been the subject of extensive preclinical investigations for the treatment and prevention of numerous pathologies including cancer, cardiovascular and Alzheimer’s disease, insulin resistance, and diabetes . Attempts to translate these findings to humans have increased in recent years but there are still fundamental gaps in our understanding of the pharmacokinetic pharmacodynamic relations and how plasma/target tissue concentrations correlate with clinical efficacy or beneficial effects on health maintenance . Such information is needed to inform the choice of optimum dose and formulation requirements, and to enhance understanding of the key modes of action for resveratrol in each pathology it is also particularly important given the notoriously low systemic bioavailability of parent resveratrol due to its rapid metabolism, which, if not taken into consideration, would affect its clinical utility.

Author(s): Hong Cai

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