Reprogramming in cancer

Immune evasion in cancer is a key impediment to effective antitumor immunity and immunotherapy, as a result of widespread immunosuppression. In cancer, both adaptive and innate immune cells have demonstrated phenotypic and functional instability by reprogramming into distinct cell subsets or states that influence tumor development, progression, and metastasis. Our findings painted a rather full picture of our present understanding of immune cell reprogramming and related processes in cancer, both with and without therapeutic intervention.

Author(s): Ashley Park

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