Reproducibility of Minimum Inhibitory Concentration for Honey Against Clinical Isolates of Methicillin-Resistant Staphylococcus aureus (MRSA)

This work aimed to support the life cycle of development for pharmaceutical product namely reproducibility of biological activity of this product. Therefore, our study included the determination of the Minimum Inhibitory Concentration (MIC) for Yemeni honey product against clinical isolates of Methicillin-Resistant Staphylococcus aureus and demonstrate the reproducibility of the MIC (Inter – Laboratories) for honey product as expresses the precision between laboratories.. The MIC for honey concentration was determined by tube agar dilution method at sender laboratory. On the other hand, the MIC was transferred into receiver site (Reproducibility) and determined with different operator and the same conditions. The results showed that, there was positive correlation between the MIC and honey concentration. Also the MIC for honey against isolated bacteria was ranged between 12.5 % and 100 %. The results showed that the different for MIC at sender and receiver sites which due to different factors. In conclusion, the receiving site guarantees that each of future results and more important be able to obtain reliable results.

Author(s): Mohammed Al-Khawlani, Adnan Al-Adhal, Mohammed Zabara, Magdi Al-Somat, Abdoalliallah Alharazi, Hassan Al-Shamahi, Ahmed Al-Arwali, Abdullah Shopit, Najeeb Ghanem, Mahmoud Ogaili and Mohammed Amood AL-Kamarany

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