Habit, a process of doing thing, formed in the brain and affected by a number of factors including drug. However, habit changes may continue throughout life pending on the goals and prevailing conditions. Hence there is need to determine neuropsychosocial relationship between habit, drug addiction and autoimmuno deficiency syndrome. Literatures were searched on the relationship between habit, drug addiction, and brain and autoimmunodeficiency syndrome with a view to identifying other possible factors responsible for social vices across the globe. Findings have shown that drugs such as adrenaline, adrenergic agonists, dopamine, serotonin and serotonin agonists, and dopaminergic agonists, among others could be responsible for psychopathy. The consequences include but not limited to conservatism, racial discrimination, religious fanaticism, war mongering, ethnic jingoism, maladministration, total collapse of values among others. Hence, drug addiction and autoimmune deficiency syndrome may cause neuropsychosocial disorder that has to do with neuronal modulation or damage affecting nigrostriadal pathway.