Quercetin Attenuating Doxorubicin Induced Hepatic, Cardiac and Renal Toxicity in Male Albino Wistar Rats

Doxorubicin (DOX) is a broad spectrum anthracycline antibiotic used to treat multiple cancers. The use of DOX is limited by significant cardiotoxicity, hepatotoxicity and nephrotoxicity. Quercetin is a dietary-flavonoid found in plants which prevents oxidant injury and protects against lipid peroxidation. The objective of the present study was to assess the possible protective role of quercetin on doxorubicin induced hepatic, cardiac and renal toxicity in male Wistar rats. Doxorubicin (10mg/kg body weight) was administered twice and quercetin (100mg/kg body weight) was administered on all the 21 days of the experimental period. Body weight, heart weight, creatine kinase in serum and heart, the activities of the antioxidant enzymes in liver, heart and kidney were decreased in doxorubicin administered rats. Liver and kidney weight, liver marker enzymes in serum, liver and kidney, lactate dehyrogenase in serum, liver, heart and kidney, urea and creatinine in serum, lipid peroxide content in liver, heart and kidney were increased. All the biochemical parameters mentioned above were restored to near normal levels on quercetin administration with doxorubicin. Administration of doxorubicin in rats altered the biochemical parameters but, did not cause much effect on the tissues such as liver, heart and kidney which is evident with histological studies.

Author(s): Sudhanshu Jambhulkar, Swathi Deshireddy, Dinesh Babu Jestadi and Latha Periyasamy

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