Protein Hox Serves as the Transcriptional Guarantee for the Asset of Cell Fate

HOX genes that encode evolutionary number of transcription factors that regulate how an organism's phenotype is arranged by its genetic composition. While HOX genes are considered to control the differentiation of Stem Cells (SC) and HOX genes are poorly controlled in cancer, there is a lack of understanding of mechanisms through which inhibition of HOX genes in SCs induces production of the cancer. The aim of this study was to examine the function of HOX genes in stem cell differentiation, specifically in embryo, infant tissue, and pluripotent stem cells and to explore the responsibilities of dysfunctional HOX genes in SCs for colorectal cancer, acute myeloid (leukaemia) production. Hox gene consists of four different clusters (Hoxa, Hoxc, Hoxb and Hoxd) and composed of 13 paralog pairs that present on four different chromosomes. The entire task of the Hox gene goes beyond the boundary of this study, but the ultimate purpose is to decide an organism's front and back body plans. 39 Hox gene components organized into HoxA, HoxC, HoxB, and HoxD were present in the mouse. The development of the phylogenetic tree is commonly used to organize new sequences of Hox into their classes. Another automatic tool is to assign Hox sequence according to the maximum sequence similarity by using BLAST technique. This profile is a matrix transcription factors that enables a score to be assigned to a series on the basis that it resembles the profile. This actually offers considerable public materials for future computer study of Hox genes, specifically in groups whereby limited taxon samples have demonstrated limitations to conclusions reached for the whole population for example, sponges without Hox, ParaHox genes. Hox pred will become an art method for the automated detection and classification of Hox genes from complete genome analysis.

Author(s): Sadaf Javed* and Farukh Azeem

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