Protective Effect of Vitis vinifera and Cichorium intybus on Stress Induced Ulcers in Albino Rats

Objective: The objective of the present investigation was to assess the protective effect of ethanolic extracts of Vitis vinifera and Cichorium intybus seeds on chronic forced swimming stress induced ulcers in albino rats. Method: The ethanolic extracts of Vitis vinifera seeds and Cichorium intybus roots were prepared and subjected to preliminary qualitative phytochemical screening. Acute toxicity of both the extracts determined in albino mice. Chronic forced swimming stress induced ulcers was evaluated by measuring the level of ulcer number, severity of gastric ulcers, pH and ulcer percentage in albino rats. Histopathological changes were observed. Results: Both the extracts did not show any mortality or a moribound status in mice upto the doses of 5g/kg body weight. The results indicated that pretreatment with ethanolic extracts of Vitis vinifera seed and Cichorium intybus root exhibited significant protective effect and prevented induction of gastric ulcers by chronic forced swimming stress at the tested doses of 250mg/kg and 500mg/kg body weight. The protective effect of Vitis vinifera seed and Cichorium intybus root at the dose of 500mg/kg body weight was comparable to the standard drug. Conclusion: On the basis of results it was concluded that Vitis vinifera and Cichorium intybus possess protective effect to combat stress induced gastric ulcers.

Author(s): Shameer Pasha, Nitin Mahurkar and K.N. Jayaveera

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