Preparation and in vitro evaluation of Chitosan Carrageenan, Chitosan-Alginate beads for controlled release of Nateglinide

The aim of the study was to prepare and evaluate beads of chitosan-carregeenan, chitosanalginate for the controlled release of nateglinide, an oral antidiabetic agent used in the management of Type 2 diabetes mellitus. Preparation of alginate-chitosan beads and hydrogel beads of chitosan-carrageenan was carried out using ionic gelation technique. The beads were evaluated for their properties like particle size distribution, drug loading, swelling behavior etc., Surface characteristics were determined using SEM (Scanning Electron Microscopy). FT-IR and XRD analysis was carried out to determine the chemical compatibility of the polymers with the drug. The polymers alginate and carrageenan showed considerable controlled release in the presence of the polymer chitosan. The ability of these polymers to retard the release of drug can be attributed to gelation medium concentration, the pH of dissolution medium and curing times. The beads were incubated in simulated gastric fluid (SGF) for the first 4 h then the SGF was replaced using simulated intestinal fluid (SIF) and the drug release was observed for the next 20 h. The chitosan coated alginate and carrageenan beads showed a release of 70% and 76% of the drug in the first 6h itself. The beads continued to release the drug for the reminder of the time.

Author(s): Abdul Althaf. Shaik, Umal Khair. Shaik and Praneetha. P

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