Preparation and Evaluation of Buccoadhesive Patches of an Antihypertensive Drug

Buccoadhesive patches of losartan potassium were prepared by solvent casting method using mucoadhesive polymers such as PVA and chitosan in different ratios. Propylene glycol was used as a plasticizer. Backing membrane was prepared by using polymer ethyl cellulose, solvents such as isopropyl alcohol and acetone. Dibutyl phthalate was used as a plasticizer in backing membrane.
Patches were subjected to physicochemical characterization evaluation such as thickness, weight uniformity, folding endurance, drug content, swelling index, surface pH study, buccoadhesion strength, buccoadhesion time, in vitro drug release, ex vivo permeation study and stability study. The FTIR spectroscopy of polymer, physical mixture and formulation indicated the compatibility of drug with excipients. Patches were found to be satisfactory when evaluated for thickness, weight uniformity, folding endurance, drug content and swelling index. The surface pH of all the patches was found to be neutral . A combination of PVA and chitosan resulted in sustained buccal drug delivery. The in vitro drug release in optimized formulation F9 was found to be 94.06 % in 8 hr.
The optimized formulation F9 also showed satisfactory pH, buccoadhesion time (520 min.), swelling index (65.6%), drug content (93.42%), buccoadhesion strength (0.1695 N), ex vivo permeation (77.97%), effective in vitro drug release (94.06) and satisfactory stability study.

Author(s): Sumedha Bansal, Mayank Bansal, Gopal

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