Potentiometric studies of the Zinc (II) complexes with some medicinal compounds and glycine in aqueous solution

The possibility of occurrence of biological relevant ciprofloxacin.HCl, pantoprazole sodium, gabapentin, chloramphenicol, ceftriaxone sodium, atenolol as medicinal drugs, and glycine as amino acid interactions was investigated in ternary systems involving medicinal compounds (drugs) and glycine as amino acid. The study was done in solution using potentiometry. The stability constants of the ternary complexes as well as the binary ones were potentiomtrically determined (T =298K, μ=0.01M, NaClO4).The order of the stability constants of ternary complexes was Zn (II)-Gabapentin-Glycine, Zn(II)-glycine-atenolol, Zn (II) - glycine-ciprofloxacin.HCl, Zn (II)- chloramphenicol-glycine , Zn(II)-glycine- ceftriaxone sodium and Zn (II) - pantoprazole sodium-glycine. ΔlogK showed that when L= medicinal compounds, the ternary complexes are less stable than the binary ones. Suggesting that no interaction occurs between the ligands in the ternary complexes. The concentration distribution of various species formed in solution was evaluated.

Author(s): Abdulbaset A. Zaida, Mazahar Farooquia , D. M. Janrao

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